Purpose: Serum calprotectin and prealbumin have been previously linked\nwith ovarian cancer. However, to date, their effectiveness in the diagnosis of\nthe disease remains uncertain. The purpose of the present study is to determine\nwhether serum prealbumin and calprotectin correlate with the stage and\ntype of histologic diagnosis. Materials-Methods: In the present study, we included\n80 women aged 30 - 45 years that had either primary ovarian cancer\n(Stages 1 and 2) with elevated levels of CA-125 (n = 40) or were healthy (n =\n40). Serum calprotectin and prealbumin levels were assessed using ELISA kits.\nStatistical analysis was performed with SPSS v.20.0 statistical software. Results:\nBoth plasma prealbumin and calprotectin levels were significantly different\nin patients with ovarian cancer compared to healthy controls. Specifically,\nserum prealbumin levels showed a level towards decreasing as the stage\nof the disease advanced (21.2 (15.5 - 30.6) in healthy controls, 12.8 (6.9 - 16)\nfor patients with stage 1 disease and 9.9 (4.0 - 15.5) for patients with stage 2\ndisease p < 0.001). Its sensitivity was 100% and specificity 82.5%. Serum calprotectin,\non the other hand, had an increasing motif (550 (100 - 2780) for\nhealthy controls, 3320 (2580 - 7930) for patients with stage 1 disease and 3825\n(2350 - 5990) for stage 2 disease p < 0.001). Similarly, its sensitivity was 100%\nand specificity 77.5%. Conclusions: Both prealbumin and calprotectin seem\nto be useful markers for the identification of patients suffering from ovarian\ncancer.
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